Pre Implantation Genetic Screening
Akruti IVF Centre provides the most advanced genetic screening or diagnosis of the embryos, Pre-implantation genetic screening (PGS) and Pre-implantation genetic diagnosis (PGD). Both these techniques help in the genetic profiling of the embryos and in detecting if there are any abnormalities in them. The abnormal embryos are then segregated as they cannot be used for the transfer into the patients or are most probably discarded.
Pre-implantation genetic screening (PGS) - It is a specialised technique that is used for the screening of the embryos which detects the chromosomal abnormality in the embryos, if any. It is also known as aneuploidy screening.
On day 5 or 6 of the embryos after IVF/ICSI, when the embryos have reached the blastocyst stage, embryo biopsy is performed by our embryologists in the IVF lab. Day 3 embryos can also be biopsied and sent for PGS. Few cells from the outer layer (trophectoderm) is removed with the help of a biopsy pipette under the microscope. A laser beam is shot onto the specific area of the layer and cells are removed from the area. These cells are then transferred into a special biopsy kit which is to be kept at -20 degree Celsius. The cells are then sent to a special genetic laboratory where the chromosomal abnormalities are tested in the embryo using the most advanced techniques.
The embryos are then immediately vitrified and stored. When we get the results of the PGS, chromosomally normal embryos are thawed and transferred into the uterus of the intended mother. The best embryos among these chromosomally normal embryos are selected for the transfer.
Pre-implantation genetic diagnosis (PGD)- It is a specialised technique used for the genetic profiling of the embryos to detect any genetic disease which can be passed onto the coming generation. The procedure for PGD technique is same as the PGS technique.